Josette Noël, Ph.D. Associate member GÉPROM Associate professor Department of Physiology Université de Montréal (Chercheur-boursier FRSQ senior)

Contact information

Current projects

• Determination of the anti-tumoral and anti-metastasic action mechanism of cyclooxygenase inhibitors (COX): studies on different cell types.
• Study of the roles of PI3-kinase, MAPkinases, PKCs, [ATP]i, pHi, phosphatases (SHP2, PP2A) and MMPs in the control of cell motility and the invasion capacity of tumoral cells.

Laboratory members

• Zeinab Daher (Ph.D. student, Biochemistry Dept.)

  zeinab_daher@hotmail.com
• Karl-Philippe Guérard (M.Sc. student, Physiology Dept.)

  karl-philippe.guerard@umontreal.ca

Selected publications

• Vadnais J, Nault G, Daher Z, Amraei M, Dodier Y, Nabi IR, Noel J.

  Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion.

  J Biol Chem. 2002 Dec 13;277(50):48342-50. Pubmed
• Lagana A, Vadnais J, Le PU, Nguyen TN, Laprade R, Nabi IR, Noel J.

  Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1.

  J Cell Sci. 2000 Oct;113 ( Pt 20):3649-62. Pubmed
• Counillon L, Noel J, Reithmeier RA, Pouyssegur J.

  Random mutagenesis reveals a novel site involved in inhibitor interaction within the fourth transmembrane segment of the Na+/H+ exchanger-1.

  Biochemistry. 1997 Mar 11;36(10):2951-9. Pubmed
• Jia Z, Vadnais J, Lu ML, Noel J, Nabi IR.

  Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation.

  Biol Cell. 2006 Jun;98(6):337-51. Pubmed
• Samane S, Noel J, Charrouf Z, Amarouch H, Haddad PS.

  Insulin-sensitizing and Anti-proliferative Effects of Argania spinosa Seed Extracts.

  Evid Based Complement Alternat Med. 2006 Sep;3(3):317-27. Pubmed
• Stock C, Mueller M, Kraehling H, Mally S, Noel J, Eder C, Schwab A.

  pH Nanoenvironment at the Surface of Single Melanoma Cells.

  Cell Physiol Biochem. 2007;20(5):679-86. Pubmed